Tumor-associated neutrophils in breast cancer: an angel or a devil?
Breast cancer is the most common malignant tumor in women, ranking first globally in both incidence and mortality rates among female malignancies, posing a severe threat to women’s physical and mental health. Neutrophils are recognized as the first line of host defense against pathogens and exert be...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593156/full |
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| _version_ | 1849331979663704064 |
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| author | Siyuan Wen Tianli Feng Yu Fan |
| author_facet | Siyuan Wen Tianli Feng Yu Fan |
| author_sort | Siyuan Wen |
| collection | DOAJ |
| description | Breast cancer is the most common malignant tumor in women, ranking first globally in both incidence and mortality rates among female malignancies, posing a severe threat to women’s physical and mental health. Neutrophils are recognized as the first line of host defense against pathogens and exert beneficial effects in the body. However, emerging evidence has demonstrated that tumor-associated neutrophils (TANs) exhibit a dual role in breast cancer progression and prognosis. Therefore, elucidating their molecular mechanisms may provide novel insights for targeted therapies, potentially improving clinical outcomes for breast cancer patients. This review summarizes the interplay between TANs and breast cancer, their underlying mechanisms, and their potential as immunotherapeutic targets. |
| format | Article |
| id | doaj-art-6a2d1e0c8619467d8001b10a6cd76fd9 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-6a2d1e0c8619467d8001b10a6cd76fd92025-08-20T03:46:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15931561593156Tumor-associated neutrophils in breast cancer: an angel or a devil?Siyuan Wen0Tianli Feng1Yu Fan2Faculty of Clinical Medicine, Southwest Medical University, Luzhou, ChinaFaculty of Clinical Medicine, Southwest Medical University, Luzhou, ChinaDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaBreast cancer is the most common malignant tumor in women, ranking first globally in both incidence and mortality rates among female malignancies, posing a severe threat to women’s physical and mental health. Neutrophils are recognized as the first line of host defense against pathogens and exert beneficial effects in the body. However, emerging evidence has demonstrated that tumor-associated neutrophils (TANs) exhibit a dual role in breast cancer progression and prognosis. Therefore, elucidating their molecular mechanisms may provide novel insights for targeted therapies, potentially improving clinical outcomes for breast cancer patients. This review summarizes the interplay between TANs and breast cancer, their underlying mechanisms, and their potential as immunotherapeutic targets.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593156/fullbreast cancertumor-associated neutrophilsimmune cellimmune microenvironmenttargeted therapy |
| spellingShingle | Siyuan Wen Tianli Feng Yu Fan Tumor-associated neutrophils in breast cancer: an angel or a devil? Frontiers in Immunology breast cancer tumor-associated neutrophils immune cell immune microenvironment targeted therapy |
| title | Tumor-associated neutrophils in breast cancer: an angel or a devil? |
| title_full | Tumor-associated neutrophils in breast cancer: an angel or a devil? |
| title_fullStr | Tumor-associated neutrophils in breast cancer: an angel or a devil? |
| title_full_unstemmed | Tumor-associated neutrophils in breast cancer: an angel or a devil? |
| title_short | Tumor-associated neutrophils in breast cancer: an angel or a devil? |
| title_sort | tumor associated neutrophils in breast cancer an angel or a devil |
| topic | breast cancer tumor-associated neutrophils immune cell immune microenvironment targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593156/full |
| work_keys_str_mv | AT siyuanwen tumorassociatedneutrophilsinbreastcanceranangeloradevil AT tianlifeng tumorassociatedneutrophilsinbreastcanceranangeloradevil AT yufan tumorassociatedneutrophilsinbreastcanceranangeloradevil |