Quantifying complexity in DNA structures with high resolution Atomic Force Microscopy

Quantifying complexity in DNA structures with high resolution Atomic Force Microscopy

Abstract DNA topology is essential for regulating cellular processes and maintaining genome stability, yet it is challenging to quantify due to the size and complexity of topologically constrained DNA molecules. By combining high-resolution Atomic Force Microscopy (AFM) with a new high-throughput au...

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Main Authors: Elizabeth P. Holmes, Max C. Gamill, James I. Provan, Laura Wiggins, Renáta Rusková, Sylvia Whittle, Thomas E. Catley, Kavit H. S. Main, Neil Shephard, Helen. E. Bryant, Neville S. Gilhooly, Agnieszka Gambus, Dušan Račko, Sean D. Colloms, Alice L. B. Pyne
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60559-x
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https://doi.org/10.1038/s41467-025-60559-x

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