Angiogenesis-osteogenesis coupling and anti-osteoclastogenesis zoledronate intermixed calcium silicate metal-organic/inorganic hybrid coating on biodegradable zinc-based intramedullary nails for osteoporotic fracture healing

Angiogenesis-osteogenesis coupling and anti-osteoclastogenesis zoledronate intermixed calcium silicate metal-organic/inorganic hybrid coating on biodegradable zinc-based intramedullary nails for osteoporotic fracture healing

Osteoporotic (OP) fractures remain a tough clinical challenge owing to their impaired healing outcome, which requires novel biomaterials with osteogenicity for effective healing. Metallic zinc (Zn) is attracting increasing attention for biodegradable intramedullary nails (IMNs) for OP fracture heali...

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Bibliographic Details
Main Authors: Junyu Qian, Haotian Qin, En Su, Jiaming Hou, Hui Zeng, Tianbing Wang, Deli Wang, Guojiang Wan, Yingqi Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-02-01
Series:Bioactive Materials
Subjects:
Angiogenesis–osteogenesis coupling
Anti-osteoclastogenesis
Biodegradable zinc
Metal-organic/inorganic hybrid coating
Intramedullary nail
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24004444
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