Sustained BMP-2 delivery via alginate microbeads and polydopamine-coated 3D-Printed PCL/β-TCP scaffold enhances bone regeneration in long bone segmental defects

Sustained BMP-2 delivery via alginate microbeads and polydopamine-coated 3D-Printed PCL/β-TCP scaffold enhances bone regeneration in long bone segmental defects

Background/Objective: Repair of long bone defects remains a major challenge in clinical practice, necessitating the use of bone grafts, growth factors, and mechanical stability. Hence, a combination therapy involving a 3D-printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) scaffold coated...

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Bibliographic Details
Main Authors: Seoyun Lee, Jae-Hun Kim, Yong-Hun Kim, Jihyeock Hong, Woo Keyoung Kim, Songwan Jin, Byung-Jae Kang
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Orthopaedic Translation
Subjects:
3D-printing
Alginate microbeads
Beta-tricalcium phosphate
Bone morphogenetic protein-2
Polycaprolactone
Segmental bone defect
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24001001
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