Metabolomics paves the way for improved drug target identification
Abstract Correctly identifying candidate drugs for protein targets is crucial for drug discovery. Despite the importance of this problem for the pharmaceutical industry, chemical screening remains a challenging task, and drug–target misidentification may contribute to failures in drug development. I...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2022-02-01
|
| Series: | Molecular Systems Biology |
| Online Access: | https://doi.org/10.15252/msb.202210914 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849331466869145600 |
|---|---|
| author | Belinda B Garana Nicholas A Graham |
| author_facet | Belinda B Garana Nicholas A Graham |
| author_sort | Belinda B Garana |
| collection | DOAJ |
| description | Abstract Correctly identifying candidate drugs for protein targets is crucial for drug discovery. Despite the importance of this problem for the pharmaceutical industry, chemical screening remains a challenging task, and drug–target misidentification may contribute to failures in drug development. In their recent study, Sauer and colleagues (Holbrook‐Smith et al, 2022) demonstrate proof‐of‐concept for a new way to identify drug–target interactions using high‐throughput metabolomics, potentially paving the way towards a universal method for predicting drug–target relationships. |
| format | Article |
| id | doaj-art-69897cf6f75a4e2cad3a755e0a0a48a2 |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-69897cf6f75a4e2cad3a755e0a0a48a22025-08-20T03:46:34ZengSpringer NatureMolecular Systems Biology1744-42922022-02-011821210.15252/msb.202210914Metabolomics paves the way for improved drug target identificationBelinda B Garana0Nicholas A Graham1Mork Family Department of Chemical Engineering and Materials Science, University of Southern CaliforniaMork Family Department of Chemical Engineering and Materials Science, University of Southern CaliforniaAbstract Correctly identifying candidate drugs for protein targets is crucial for drug discovery. Despite the importance of this problem for the pharmaceutical industry, chemical screening remains a challenging task, and drug–target misidentification may contribute to failures in drug development. In their recent study, Sauer and colleagues (Holbrook‐Smith et al, 2022) demonstrate proof‐of‐concept for a new way to identify drug–target interactions using high‐throughput metabolomics, potentially paving the way towards a universal method for predicting drug–target relationships.https://doi.org/10.15252/msb.202210914 |
| spellingShingle | Belinda B Garana Nicholas A Graham Metabolomics paves the way for improved drug target identification Molecular Systems Biology |
| title | Metabolomics paves the way for improved drug target identification |
| title_full | Metabolomics paves the way for improved drug target identification |
| title_fullStr | Metabolomics paves the way for improved drug target identification |
| title_full_unstemmed | Metabolomics paves the way for improved drug target identification |
| title_short | Metabolomics paves the way for improved drug target identification |
| title_sort | metabolomics paves the way for improved drug target identification |
| url | https://doi.org/10.15252/msb.202210914 |
| work_keys_str_mv | AT belindabgarana metabolomicspavesthewayforimproveddrugtargetidentification AT nicholasagraham metabolomicspavesthewayforimproveddrugtargetidentification |