Challenges and Opportunities in DNA Encoded Library Screens
In our lab we have been developing techniques that attempt to capture or amplify signals in pooled compound mixtures for several years. DNA encoded libraries (DELs) are the most widely used pooled mixtures in early drug discovery. DELs are massive collections of small molecules, where each individua...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2025-03-01
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| Series: | CHIMIA |
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| Online Access: | https://www.chimia.ch/chimia/article/view/7887 |
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| author | Basilius Sauter Pinwen Cai Koder Dagher Chiara Disraeli Athira Kakkolliyil Prakash Lukas Schneider Ángel Cores Esperon Dennis Gillingham |
| author_facet | Basilius Sauter Pinwen Cai Koder Dagher Chiara Disraeli Athira Kakkolliyil Prakash Lukas Schneider Ángel Cores Esperon Dennis Gillingham |
| author_sort | Basilius Sauter |
| collection | DOAJ |
| description | In our lab we have been developing techniques that attempt to capture or amplify signals in pooled compound mixtures for several years. DNA encoded libraries (DELs) are the most widely used pooled mixtures in early drug discovery. DELs are massive collections of small molecules, where each individual molecule is covalently linked to a unique DNA strand that can serve as an identification tag by sequencing. The industry standard for selecting DELs is affinity enrichment, which inherently can only search for direct binding. We outline here two of the ways that we are attempting to extend the potential of DEL screens into new areas.
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| format | Article |
| id | doaj-art-68cee5ae3e2f4ee6a90e8e2c947cea02 |
| institution | Kabale University |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 2025-03-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-68cee5ae3e2f4ee6a90e8e2c947cea022025-08-20T03:53:27ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242025-03-0179310.2533/chimia.2025.158Challenges and Opportunities in DNA Encoded Library ScreensBasilius Sauter0https://orcid.org/0000-0002-3199-3397Pinwen Cai1Koder Dagher2Chiara Disraeli3Athira Kakkolliyil Prakash4Lukas Schneider5Ángel Cores Esperon6Dennis Gillingham7Department of Chemistry, University of Basel, CH-4056 Basel, Switzerland.Department of Chemistry, University of Basel, CH-4056 Basel, Switzerland.Department of Chemistry, University of Basel, CH-4056 Basel, Switzerland.Department of Chemistry, University of Basel, CH-4056 Basel, Switzerland.Department of Chemistry, University of Basel, CH-4056 Basel, Switzerland.Department of Chemistry, University of Basel, CH-4056 Basel, Switzerland.Department of Chemistry, University of Basel, CH-4056 Basel, Switzerland.Department of Chemistry, University of Basel, CH-4056 Basel, Switzerland.In our lab we have been developing techniques that attempt to capture or amplify signals in pooled compound mixtures for several years. DNA encoded libraries (DELs) are the most widely used pooled mixtures in early drug discovery. DELs are massive collections of small molecules, where each individual molecule is covalently linked to a unique DNA strand that can serve as an identification tag by sequencing. The industry standard for selecting DELs is affinity enrichment, which inherently can only search for direct binding. We outline here two of the ways that we are attempting to extend the potential of DEL screens into new areas. https://www.chimia.ch/chimia/article/view/7887BiotechnologyChemical biologyDNA encoded librariesMedicinal chemistry |
| spellingShingle | Basilius Sauter Pinwen Cai Koder Dagher Chiara Disraeli Athira Kakkolliyil Prakash Lukas Schneider Ángel Cores Esperon Dennis Gillingham Challenges and Opportunities in DNA Encoded Library Screens CHIMIA Biotechnology Chemical biology DNA encoded libraries Medicinal chemistry |
| title | Challenges and Opportunities in DNA Encoded Library Screens |
| title_full | Challenges and Opportunities in DNA Encoded Library Screens |
| title_fullStr | Challenges and Opportunities in DNA Encoded Library Screens |
| title_full_unstemmed | Challenges and Opportunities in DNA Encoded Library Screens |
| title_short | Challenges and Opportunities in DNA Encoded Library Screens |
| title_sort | challenges and opportunities in dna encoded library screens |
| topic | Biotechnology Chemical biology DNA encoded libraries Medicinal chemistry |
| url | https://www.chimia.ch/chimia/article/view/7887 |
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