CLCF1 contributes to high-glucose-induced EndMT by modulating JAK2/STAT3 signaling

CLCF1 contributes to high-glucose-induced EndMT by modulating JAK2/STAT3 signaling

Abstract Background Cardiotrophin-like cytokine factor 1 (CLCF1) is shown to enhance glomerular albumin permeability, contributing to proteinuria. However, its specific involvement in diabetic kidney disease (DKD) remains undefined. This study aimed to explore the mechanistic contribution of CLCF1 t...

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Bibliographic Details
Main Authors: Rongrong Deng, Kaiying He, Qicai You, Wenkai Zhang, Xuezhen Ma, Xiaochun Zhou, Yuke Kong, Jianqin Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Cardiotrophin-like cytokine factor 1
Diabetic kidney disease
High glucose
Human renal glomerular endothelial cells
Endothelial mesenchymal transition
Janus kinases 2
Online Access:https://doi.org/10.1186/s40001-025-02932-6
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https://doi.org/10.1186/s40001-025-02932-6

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