Efficacy and safety of human umbilical cord-derived mesenchymal stem cells versus placebo added to second-line therapy in patients with steroid-refractory acute graft-versus-host disease: a multicentre, randomized, double-blind, phase 2 trial
Abstract Background Failure of systemic corticosteroid therapy is common in patients with newly diagnosed acute graft-versus-host disease (aGVHD) above grade II. Mesenchymal stem cells (MSCs) have been used as a tolerable and potentially effective second-line therapy for steroid-refractory aGVHD (SR...
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Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2024-11-01
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Series: | BMC Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12916-024-03782-5 |
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