Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells

Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells

Abstract Brain endothelial cells experience mechanical forces in the form of blood flow-mediated shear stress and underlying matrix stiffness, but intersectional contributions of these factors towards blood–brain barrier (BBB) impairment and neurovascular dysfunction have not been extensively studie...

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Bibliographic Details
Main Authors: Alexis K. Yates, Heather Murray, Andrew Kjar, Daniel Chavarria, Haley Masters, Hyosung Kim, Alexander P. Ligocki, Angela L. Jefferson, Ethan S. Lippmann
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Fluids and Barriers of the CNS
Subjects:
Brain microvascular endothelial cell
Vascular stiffening
Fluid shear stress
In vitro models
Inflammation
Online Access:https://doi.org/10.1186/s12987-025-00683-4
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https://doi.org/10.1186/s12987-025-00683-4

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