The collagenase-induced osteoarthritis (CIOA) model: Where mechanical damage meets inflammation

The collagenase-induced osteoarthritis (CIOA) model: Where mechanical damage meets inflammation

Objective: To characterize inflammatory and mechanical changes in the collagenase-induced OA (CIOA) model in rats. Design: Skeletally mature, 6-month-old Wistar rats received unilateral intraarticular injections of saline, 500 U or 1000 U of collagenase on days 0 and 2 of the study. Joint tissues we...

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Main Authors: Patrick Weber, Kajetana Bevc, David Fercher, Sami Kauppinen, Shipin Zhang, Maryam Asadikorayem, Lucia Baixauli Marin, Tanqi Zhang, Tuomas Frondelius, Gian Salzmann, Valentino Bruhin, Jakob Hax, Gonçalo Barreto, Mikko A.J. Finnilä, Marcy Zenobi-Wong
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Osteoarthritis
Animal model
Collagenase
Synovitis
Computed tomography
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913124001067
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