Case Report: Activated PI3-kinase-δ syndrome and ovarian malignancies: a case series from the European ESID-APDS registry

Case Report: Activated PI3-kinase-δ syndrome and ovarian malignancies: a case series from the European ESID-APDS registry

Activated phosphoinositide-3-kinase-delta (PI3Kδ) syndrome (APDS) is an autosomal dominant inborn error of immunity (IEI) characterized by combined immunodeficiency and immune dysregulation with increased risk for lymphoma and other non-lymphoid malignancies. We describe five patients with ovarian m...

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Bibliographic Details
Main Authors: Maria Pia Esposto, Nizar Mahlaoui, Hassan Abolhassani, Koen Van Aerde, Simone Cesaro, Anita Chandra, Stephan Ehl, Sven Kracker, Felipe Suarez, Vincent Barlogis, Alice Parisi, Maria Elena Maccari, Matteo Chinello
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
activated PI3-kinase-δ syndrome
ovarian cancer
ovarian malignancies
IEI
inborn errors of immunity
female
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572194/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1572194/full

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