Depressed TFAM promotes acetaminophen-induced hepatotoxicity regulated by DDX3X–PGC1α–NRF2 signaling pathway

Depressed TFAM promotes acetaminophen-induced hepatotoxicity regulated by DDX3X–PGC1α–NRF2 signaling pathway

Abstract Background Acetaminophen (APAP)-induced acute liver injury (AILI) is the most prevalent cause of acute liver failure and mitochondrial dysfunction plays a dominant role in the pathogenesis of AILI. Mitochondrial transcription factor A (TFAM) is an important marker for maintaining mitochondr...

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Main Authors: Sisi Chen, Yaling Cao, Zihao Fan, Ling Xu, Zhenzhen Pan, Yao Gao, Linlin Wei, Qiaoxin Wei, Yuan Tian, Xiangying Zhang, Mei Liu, Feng Ren
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Acetaminophen
Acute liver injury
Mitochondrial transcription factor A
Respiratory factor 2
Peroxisome proliferator-activated receptor γ-coactivator-1α
Online Access:https://doi.org/10.1186/s10020-024-01017-0
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https://doi.org/10.1186/s10020-024-01017-0

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