SIRT1 Alleviates Mitochondrial Fission and Necroptosis in Cerebral Ischemia/Reperfusion Injury via SIRT1–RIP1 Signaling Pathway

SIRT1 Alleviates Mitochondrial Fission and Necroptosis in Cerebral Ischemia/Reperfusion Injury via SIRT1–RIP1 Signaling Pathway

ABSTRACT Programmed cell death, including necroptosis, plays a critical role in the pathogenesis of cerebral ischemia/reperfusion injury (CIRI). Silent information regulator 1 (SIRT1) has been identified as a potential therapeutic target for CIRI, yet its precise role in regulating necroptosis remai...

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Bibliographic Details
Main Authors: Xuan Wei, Hanjing Guo, Guangshan Huang, Haoyue Luo, Lipeng Gong, Pan Meng, Jiyong Liu, Wenli Zhang, Zhigang Mei
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:MedComm
Subjects:
cerebral ischemia/reperfusion injury
DRP1
mitochondrial fission
necroptosis
RIP1
SIRT1
Online Access:https://doi.org/10.1002/mco2.70118
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https://doi.org/10.1002/mco2.70118

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