Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor

Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor

<b>Background/objective:</b> The glucocorticoid receptor (GR) is critical in regulating cortisol production during stress. This makes it a key target for treating conditions associated with hypothalamic–pituitary–adrenal (HPA) axis dysregulation, such as mental disorders. This study expl...

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Bibliographic Details
Main Authors: Ovinuchi Ejiohuo, Donald Bajia, Joanna Pawlak, Aleksandra Szczepankiewicz
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomedicines
Subjects:
glucocorticoid receptor
asoprisnil
in silico drug target profiling
ligand–protein interaction
computational chemistry
stress-related mental disorders
Online Access:https://www.mdpi.com/2227-9059/12/12/2745
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