Advancing diagnosis and treatment for human African trypanosomiasis in Nigeria: challenges and future directions
Human African trypanosomiasis (HAT), commonly known as sleeping sickness, remains a significant health threat in sub-Saharan Africa. In Nigeria, the challenges of diagnosing and treating HAT are profound, especially in resource-constrained, remote areas. This article offers a perspective on the barr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Tropical Diseases |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fitd.2024.1503421/full |
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| author | Kelly Zongo Rolayo Toyin Emmanuel |
| author_facet | Kelly Zongo Rolayo Toyin Emmanuel |
| author_sort | Kelly Zongo |
| collection | DOAJ |
| description | Human African trypanosomiasis (HAT), commonly known as sleeping sickness, remains a significant health threat in sub-Saharan Africa. In Nigeria, the challenges of diagnosing and treating HAT are profound, especially in resource-constrained, remote areas. This article offers a perspective on the barriers to timely diagnosis and treatment of HAT in Nigeria, drawing from recent developments in diagnostic techniques and case management approaches. The focus is on improving the current diagnostic framework, decentralizing the validation process, and streamlining drug distribution to effectively halt the transmission of HAT. We discuss the potential of simple and rapid molecular diagnostics, particularly the lyophilized LAMP test, as a game-changer in resource-limited settings and the need for a national repository of drugs to ensure timely therapeutic interventions. This article also explores future directions for the elimination of HAT in Nigeria, highlighting the importance of policy reforms and increased investment in diagnostic infrastructure. |
| format | Article |
| id | doaj-art-65b80f33805f418da7d099c37e6c744c |
| institution | Kabale University |
| issn | 2673-7515 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Tropical Diseases |
| spelling | doaj-art-65b80f33805f418da7d099c37e6c744c2025-01-06T06:59:31ZengFrontiers Media S.A.Frontiers in Tropical Diseases2673-75152025-01-01510.3389/fitd.2024.15034211503421Advancing diagnosis and treatment for human African trypanosomiasis in Nigeria: challenges and future directionsKelly Zongo0Rolayo Toyin Emmanuel1The International Programs Team, The End Neglected Tropical Diseases (END) Fund, New York, NY, United StatesPan African Tsetse and Trypanosomiasis Eradication Campaign-Nigeria, Nigerian Institute for Trypanosomiasis and Onchocerciasis Research Headquarters, Kaduna, NigeriaHuman African trypanosomiasis (HAT), commonly known as sleeping sickness, remains a significant health threat in sub-Saharan Africa. In Nigeria, the challenges of diagnosing and treating HAT are profound, especially in resource-constrained, remote areas. This article offers a perspective on the barriers to timely diagnosis and treatment of HAT in Nigeria, drawing from recent developments in diagnostic techniques and case management approaches. The focus is on improving the current diagnostic framework, decentralizing the validation process, and streamlining drug distribution to effectively halt the transmission of HAT. We discuss the potential of simple and rapid molecular diagnostics, particularly the lyophilized LAMP test, as a game-changer in resource-limited settings and the need for a national repository of drugs to ensure timely therapeutic interventions. This article also explores future directions for the elimination of HAT in Nigeria, highlighting the importance of policy reforms and increased investment in diagnostic infrastructure.https://www.frontiersin.org/articles/10.3389/fitd.2024.1503421/fullsleeping sicknessAfrican trypanosomiasistsetse flyNigeriadiagnosispolicy |
| spellingShingle | Kelly Zongo Rolayo Toyin Emmanuel Advancing diagnosis and treatment for human African trypanosomiasis in Nigeria: challenges and future directions Frontiers in Tropical Diseases sleeping sickness African trypanosomiasis tsetse fly Nigeria diagnosis policy |
| title | Advancing diagnosis and treatment for human African trypanosomiasis in Nigeria: challenges and future directions |
| title_full | Advancing diagnosis and treatment for human African trypanosomiasis in Nigeria: challenges and future directions |
| title_fullStr | Advancing diagnosis and treatment for human African trypanosomiasis in Nigeria: challenges and future directions |
| title_full_unstemmed | Advancing diagnosis and treatment for human African trypanosomiasis in Nigeria: challenges and future directions |
| title_short | Advancing diagnosis and treatment for human African trypanosomiasis in Nigeria: challenges and future directions |
| title_sort | advancing diagnosis and treatment for human african trypanosomiasis in nigeria challenges and future directions |
| topic | sleeping sickness African trypanosomiasis tsetse fly Nigeria diagnosis policy |
| url | https://www.frontiersin.org/articles/10.3389/fitd.2024.1503421/full |
| work_keys_str_mv | AT kellyzongo advancingdiagnosisandtreatmentforhumanafricantrypanosomiasisinnigeriachallengesandfuturedirections AT rolayotoyinemmanuel advancingdiagnosisandtreatmentforhumanafricantrypanosomiasisinnigeriachallengesandfuturedirections |