Metabolic profiling unveils enhanced antibacterial synergy of polymyxin B and teixobactin against multi-drug resistant Acinetobacter baumannii

Metabolic profiling unveils enhanced antibacterial synergy of polymyxin B and teixobactin against multi-drug resistant Acinetobacter baumannii

Abstract This untargeted metabolomics study investigated the synergistic antibacterial activity of polymyxin B and Leu10-teixobactin, a depsipeptide inhibitor of cell wall biosynthesis. Checkerboard microdilution assays revealed a significant synergy against polymyxin-susceptible and -resistant A. b...

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Main Authors: Maytham Hussein, Zhisen Kang, Stephanie L. Neville, Rafah Allobawi, Varsha Thrombare, Augustine Jing Jie Koh, Jonathan Wilksch, Simon Crawford, Mudher Khudhur Mohammed, Christopher A. McDevitt, Mark Baker, Gauri G. Rao, Jian Li, Tony Velkov
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Polymyxin B
Teixobactin
A. baumannii
Antimicrobial resistance
Metabolomics
Online Access:https://doi.org/10.1038/s41598-024-78769-6
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