Semi-rational engineering of an α-L-fucosidase for regioselective synthesis of fucosyl-N-acetylglucosamine disaccharides

Semi-rational engineering of an α-L-fucosidase for regioselective synthesis of fucosyl-N-acetylglucosamine disaccharides

α-L-Fucosidases are attractive biocatalysts for the production of bioactive fucosylated oligosaccharides, however, poor regioselectivity and activity for transglycosylation have significantly limited their applications. We have recently derived an α-L-Fucosidase, BF3242, from Bacteroides fragilis NC...

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Bibliographic Details
Main Authors: Peng Liu, Xiaodi Chen, Xueting Cao, Yuying Wang, Yafei Gao, Li Xu, Xukai Jiang, Min Xiao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Food Chemistry: Molecular Sciences
Subjects:
α-L-fucosidase
Enzyme engineering
Regioselectivity
Transglycosylation
Fucosyl-N-acetylglucosamine disaccharide
Online Access:http://www.sciencedirect.com/science/article/pii/S266656622500005X
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