1-(5-ACETYL-3-METHYL-6-PHENYL-5H-[1,2,4]TRIAZOLO [3,4-b][1,3,4]THIADIAZIN-7-YL)-ETHANONE: DOSE-DEPENDENCE OF ANALGESIC EFFECT, LACK OF OPIOIDERGIC MECHANISM OF ACTION, EFFECT ON BEHAVIORAL REACTIONS AND ACUTE TOXICITY

1-(5-ACETYL-3-METHYL-6-PHENYL-5H-[1,2,4]TRIAZOLO [3,4-b][1,3,4]THIADIAZIN-7-YL)-ETHANONE: DOSE-DEPENDENCE OF ANALGESIC EFFECT, LACK OF OPIOIDERGIC MECHANISM OF ACTION, EFFECT ON BEHAVIORAL REACTIONS AND ACUTE TOXICITY

Derivatives of 5,7-diacyl-3-H(alkyl)-6-aryl-5H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazine. Aim. To evaluate the dose dependence of the analgesic effect of the compound IFT_247, the participation of the opioidergic component in the mechanism of action of this compound, its influence on behavioral r...

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Bibliographic Details
Main Authors: Andriy Koval, Sergiy Shtrygol
Format: Article
Language:English
Published: Danylo Halytsky Lviv National Medical University 2023-12-01
Series:Acta Medica Leopoliensia
Subjects:
5,7-diacyl-3-h(alkyl)-6-aryl-5h-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives
analgesic effect
dose dependence
mechanism of action
acute toxicity
Online Access:https://amljournal.com/index.php/journal/article/view/375
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