Synthesis, enzyme inhibition, and docking studies of new schiff bases of disalicylic acid methylene-based derivatives as dual-target antibacterial agents

Synthesis, enzyme inhibition, and docking studies of new schiff bases of disalicylic acid methylene-based derivatives as dual-target antibacterial agents

IntroductionBacteria have acquired resistance to almost all antibiotics currently in use due to their extensive, broad, and improper utilization over a prolonged period. DNA gyrase and DHFR exhibit significant promise as targets for antibacterial therapeutics.MethodsWe have developed a series of dis...

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Main Authors: Lamya H. Al-Wahaibi, Mohamed A. Mahmoud, Hayat Ali Alzahrani, Hesham A. Abou-Zied, Alshaimaa Abdelmoez, Bahaa G. M. Youssif, Stefan Bräse, Safwat M. Rabea
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Chemistry
Subjects:
bacterial resistance
biofilm
DNA
isatin
salicylic acid
bactericidal
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1493906/full
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https://www.frontiersin.org/articles/10.3389/fchem.2024.1493906/full

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