Eosinophils mitigate intestinal fibrosis while promoting inflammation in a chronic DSS colitis model and co-culture model with fibroblasts

Eosinophils mitigate intestinal fibrosis while promoting inflammation in a chronic DSS colitis model and co-culture model with fibroblasts

Abstract Eosinophils were previously reported to play a role in intestinal inflammation and fibrosis. Whether this is as a bystander or as an active participant is still up for debate. Moreover, data describing a causal relationship between eosinophils and intestinal fibrosis are scarce. We here aim...

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Main Authors: Inge Jacobs, Sara Deleu, Bo-Jun Ke, Jonathan Cremer, Ellen Dilissen, Gert De Hertogh, Tobie Martens, Pieter Vanden Berghe, Gianluca Matteoli, Séverine Vermeire, Christine Breynaert, Tim Vanuytsel, Bram Verstockt
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Eosinophils
Pro-inflammatory
Anti-fibrotic
In vitro co-culture
DSS colitis model
Online Access:https://doi.org/10.1038/s41598-024-78602-0
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https://doi.org/10.1038/s41598-024-78602-0

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