Dopamine D1 receptor agonist alleviates post-weaning isolation-induced neuroinflammation and depression-like behaviors in female mice

Abstract Background Major depressive disorder is a significant global cause of disability, particularly among adolescents. The dopamine system and nearby neuroinflammation, crucial for regulating mood and processing rewards, are central to the frontostriatal circuit, which is linked to depression. T...

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Main Authors: Zi-Wei Zhao, Yun-Chen Wang, Pei-Chun Chen, Shun-Fen Tzeng, Po-See Chen, Yu-Min Kuo
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Behavioral and Brain Functions
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Online Access:https://doi.org/10.1186/s12993-025-00269-y
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