Spermidine reduces ISGylation and enhances ISG15–USP18 interaction

Abstract The expression of ubiquitin-like molecule interferon-stimulated gene 15 kDa (ISG15) and its post-translational modification (ISGylation) are significantly activated by interferons or pathogen infections, highlighting their roles in innate immune responses. Over 1100 proteins have been ident...

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Bibliographic Details
Main Authors: Haruka Etori, Riko Asoshina, Takayuki Obita, Fumihiko Okumura
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-01425-0
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