Glial maturation factor-β deficiency prevents oestrogen deficiency-induced bone loss by remodelling the actin network to suppress adipogenesis of bone marrow mesenchymal stem cells

Glial maturation factor-β deficiency prevents oestrogen deficiency-induced bone loss by remodelling the actin network to suppress adipogenesis of bone marrow mesenchymal stem cells

Abstract An imbalance between the adipogenesis and osteogenesis of bone marrow mesenchymal stem cells (BMSCs) is considered the basic pathogenesis of osteoporosis. Although actin cytoskeleton remodelling plays a crucial role in the differentiation of BMSCs, the role of actin cytoskeleton remodelling...

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Main Authors: Jun Xu, Zhongyue Huang, Si Shi, Jiangni Xia, Guangnan Chen, Kaifeng Zhou, Yiming Zhang, Chong Bian, Yuqin Shen, Xiaofan Yin, Lixia Lu, Huijie Gu
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07234-z
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https://doi.org/10.1038/s41419-024-07234-z

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