Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Abstract Microglia/macrophages accumulate at the lesion site by switching toward pro‐inflammatory (M1)‐dominant phenotype at the acute phase following spinal cord injury (SCI). Such biased polarization shapes the functional outcomes by expanding tissue damage. In the present study, the astrocytic en...

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Bibliographic Details
Main Authors: Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
thrombin
endothelin‐1
astrocytes
microglia
phenotype
Online Access:https://doi.org/10.1002/advs.202507215
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https://doi.org/10.1002/advs.202507215

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