Synergistic effects of combined hypnotic drugs on sleep in mice

Synergistic effects of combined hypnotic drugs on sleep in mice

Study objectivesTo investigate the interaction and potential mechanisms of the combined administration of dexmedetomidine (DMED) and eszopiclone (ESZ) on sleep in mice.MethodsThe effects of DMED, ESZ and the combination of the two drugs on the sleep status of mice were investigated by using the loss...

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Bibliographic Details
Main Authors:	Rui Bai, Chu Wang, Fanghui Wu, Yifeng Yin, Yanli Liu, Yuan Gao, Yunyang Song
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Pharmacology
Subjects:	sleep hypnotics dexmedetomidine eszopiclone combination synergistic effects
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1596813/full
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