Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions

Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions

Abstract The ERK1/2 MAP kinase pathway is an evolutionarily conserved signaling module that controls many fundamental physiological processes. Deregulated activity of ERK1/2 MAP kinases is associated with developmental syndromes and several human diseases. Despite the importance of this pathway, a c...

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Bibliographic Details
Main Authors: Mathieu Courcelles, Christophe Frémin, Laure Voisin, Sébastien Lemieux, Sylvain Meloche, Pierre Thibault
Format: Article
Language:English
Published: Springer Nature 2013-05-01
Series:Molecular Systems Biology
Subjects:
bioinformatics
cell signaling
MAP kinases
phosphoproteomics
phosphorylation dynamics
Online Access:https://doi.org/10.1038/msb.2013.25
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https://doi.org/10.1038/msb.2013.25

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