Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy

Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy

T-cell lymphomas (TCLs) are heterogeneous malignancies with limited treatment options and poor outcomes. The efficacy of traditional T-cell therapies, including chimeric antigen receptor (CAR) T cells, is often constrained by immunosuppressive factors and the tumor microenvironment. On the other han...

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Bibliographic Details
Main Authors: Baijin Xia, Huolun Feng, Xinmiao Jiang, Jialing Guo, Keming Lin, Wenxing Zhang, Fan Xing, Lixue Cao, Yong Li, Hui Zhang, Xu Zhang, Wenyu Li, Fei Yu
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Pharmacological Research
Subjects:
Granzyme B
Nanoparticle
Ferritin
Nanobody
Tumor targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000532
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