Drug review: mTOR-inhibitor therapy in fetal cardiac rhabdomyoma—a tightrope walk

Drug review: mTOR-inhibitor therapy in fetal cardiac rhabdomyoma—a tightrope walk

ObjectiveMechanistic/mammalian target of rapamycin (mTOR) inhibitors have been used successfully to reduce the size of cardiac rhabdomyomas. However, the number of published cases is small and thus there is no consensus about therapeutic approaches, especially regarding dosing regimens and safety pr...

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Bibliographic Details
Main Authors: Nadine Muschel, Michaela Höck, Elke Griesmaier, Samira Abdel Azim, Elisabeth Ralser, Christina Schreiner, Elisabeth Schermer, Ursula Kiechl-Kohlendorfer, Irene Mutz-Dehbalaie, Miriam Michel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pediatrics
Subjects:
adverse effects
fetal cardiac tumor
rhabdomyoma
sirolimus
re-entry tachycardia
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1649341/full
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