Intranasal phage treatment overcomes the limitations posed by antibody-mediated neutralization in bacteriophage therapy for Pseudomonas aeruginosa lung infections

Intranasal phage treatment overcomes the limitations posed by antibody-mediated neutralization in bacteriophage therapy for Pseudomonas aeruginosa lung infections

Background: Our recent work discovered that intranasal inhalation of phage (KKP10) and Ca-EDTA substantially re-sensitized multidrug-resistant P. aeruginosa to ceftazidime/avibactam. Notably, the route of phage administration was reported to influence the development of antibody-mediated neutralizat...

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Bibliographic Details
Main Authors: Dhammika Leshan Wannigama, Cameron Hurst, Peter N Monk, Paul G. Higgins, Tanittha Chatsuwan, Anthony Kicic, Parichart Hongsing, Shuichi Abe, Stephen M Stick
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Antibody-mediated neutralization
Bacteriophage treatment
Pulmonary infection
Pseudomonas aeruginosa
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716524004065
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