A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles
BackgroundImmune checkpoint inhibitors (ICIs) have transformed oncological treatment by modulating immune responses against tumors. However, their efficacy is subject to inter-patient variability and is associated with immune-related adverse events (irAEs). The human gut microbiota, a complex microb...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519498/full |
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| author | Ziqi Zhao Kun Xu Boqian Hu Yizhuo Jiang Xisheng Xu Yuliang Liu |
| author_facet | Ziqi Zhao Kun Xu Boqian Hu Yizhuo Jiang Xisheng Xu Yuliang Liu |
| author_sort | Ziqi Zhao |
| collection | DOAJ |
| description | BackgroundImmune checkpoint inhibitors (ICIs) have transformed oncological treatment by modulating immune responses against tumors. However, their efficacy is subject to inter-patient variability and is associated with immune-related adverse events (irAEs). The human gut microbiota, a complex microbial ecosystem, is increasingly implicated in modulating responses to ICIs. This bibliometric analysis examines the 100 most-cited articles to elucidate trends and advancements in research concerning the gut microbiota’s impact on ICI efficacy.MethodsA systematic literature retrieval was conducted within the Web of Science Core Collection (WoSCC), focusing on the 100 most-cited articles. VOSviewer and CiteSpace were utilized for bibliometric analysis, examining collaborative patterns and keyword co-occurrences. The relationship between citing and cited entities was analyzed, and burst ranking identified research hotspots based on citation frequency.ResultsThe 100 most-cited publications encompassed a range of disciplines, with a predominance of oncological research. The United States and China were leading in publication volume, with France and Canada also contributing significantly. French institutions, particularly INSERM and Université Paris Cite, were prolific. Routy, Bertrand and Zitvogel, Laurence were prominent among high-impact authors. Dominant keywords included “gut microbiota,” “immunotherapy,” “efficacy,” and “cancer.” The article by Routy et al. (2018) was the most frequently cited.ConclusionsThis study highlights the significant role of the gut microbiota in ICI development and efficacy, emphasizing the necessity for international and interdisciplinary collaboration. The research is progressively focusing on managing immunotherapy side effects and optimizing treatment strategies. Challenges, including individual variability in gut microbiota composition, persist. Further research is imperative to exploit the potential of the gut microbiota in cancer therapy, advocating for personalized approaches and a more profound comprehension of the underlying mechanisms. |
| format | Article |
| id | doaj-art-63799042bc0747e5a6e7dd57e9a3e9fc |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-63799042bc0747e5a6e7dd57e9a3e9fc2025-01-16T06:10:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15194981519498A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articlesZiqi Zhao0Kun Xu1Boqian Hu2Yizhuo Jiang3Xisheng Xu4Yuliang Liu5School of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaHebei Provincial Hospital of Traditional Chinese Medicine, Hebei University of Chinese Medicine, Shijiazhuang, ChinaSchool of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaBackgroundImmune checkpoint inhibitors (ICIs) have transformed oncological treatment by modulating immune responses against tumors. However, their efficacy is subject to inter-patient variability and is associated with immune-related adverse events (irAEs). The human gut microbiota, a complex microbial ecosystem, is increasingly implicated in modulating responses to ICIs. This bibliometric analysis examines the 100 most-cited articles to elucidate trends and advancements in research concerning the gut microbiota’s impact on ICI efficacy.MethodsA systematic literature retrieval was conducted within the Web of Science Core Collection (WoSCC), focusing on the 100 most-cited articles. VOSviewer and CiteSpace were utilized for bibliometric analysis, examining collaborative patterns and keyword co-occurrences. The relationship between citing and cited entities was analyzed, and burst ranking identified research hotspots based on citation frequency.ResultsThe 100 most-cited publications encompassed a range of disciplines, with a predominance of oncological research. The United States and China were leading in publication volume, with France and Canada also contributing significantly. French institutions, particularly INSERM and Université Paris Cite, were prolific. Routy, Bertrand and Zitvogel, Laurence were prominent among high-impact authors. Dominant keywords included “gut microbiota,” “immunotherapy,” “efficacy,” and “cancer.” The article by Routy et al. (2018) was the most frequently cited.ConclusionsThis study highlights the significant role of the gut microbiota in ICI development and efficacy, emphasizing the necessity for international and interdisciplinary collaboration. The research is progressively focusing on managing immunotherapy side effects and optimizing treatment strategies. Challenges, including individual variability in gut microbiota composition, persist. Further research is imperative to exploit the potential of the gut microbiota in cancer therapy, advocating for personalized approaches and a more profound comprehension of the underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519498/fullbibliometrics analysiscancer patientsgut microbiotaimmune checkpoint inhibitorsimmunotherapy |
| spellingShingle | Ziqi Zhao Kun Xu Boqian Hu Yizhuo Jiang Xisheng Xu Yuliang Liu A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles Frontiers in Immunology bibliometrics analysis cancer patients gut microbiota immune checkpoint inhibitors immunotherapy |
| title | A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles |
| title_full | A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles |
| title_fullStr | A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles |
| title_full_unstemmed | A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles |
| title_short | A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles |
| title_sort | bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients analysis of the top 100 cited articles |
| topic | bibliometrics analysis cancer patients gut microbiota immune checkpoint inhibitors immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519498/full |
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