DDTC-Cu(I) inhibits human osteosarcoma cells growth by repressing MET/PI3K/AKT signaling pathway

DDTC-Cu(I) inhibits human osteosarcoma cells growth by repressing MET/PI3K/AKT signaling pathway

Abstract Osteosarcoma (OS) is a frequently occurring bone malignancy with increased metastatic properties, causing deaths in large numbers around the world. Disulfiram (DSF) is clinically utilized to treat alcohol dependency and has been indicated to bind Cu(I) in-vivo to form DDTC-Cu(I), which has...

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Main Authors: Ruhao Zhou, Lei Yan, Kun Zhang, Song Chen, Yang Yu, Xiaochun Wei, Yongchun Pan, Chaojian Xu, Xiaojuan Sun, Zhi Lv, Pengcui Li, Xiaochen Qiao, Yi Feng, Zhi Tian
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Disulfiram
DDTC-Cu(I)
Osteosarcoma
RNA seq
MET/PI3K/Akt signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-06748-6
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https://doi.org/10.1038/s41598-025-06748-6

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