Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles
The utilization of silver nanoparticles (AgNPs) in diverse fields, including medicine, is on the rise, leading to the development of a non-toxic and environmentally friendly synthesis method. This study presents a straightforward and stable one-step synthesis of AgNPs using an aqueous extract of Amy...
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| Format: | Article |
| Language: | English |
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Iranian Chemical Society
2024-04-01
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| Series: | Nanochemistry Research |
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| Online Access: | http://www.nanochemres.org/article_187338_4a421ee450e7ef90c8797513a780f68d.pdf |
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| author | Mojgan Taebi Mahnaz Amiri Niloofar Rashidi Mahsa Sistani Sanaz Hadizadeh Razieh Razavi Ali Reza Farzinnejad Meysam Ahmadi Zeidabadi Somayeh Karami Mohajeri |
| author_facet | Mojgan Taebi Mahnaz Amiri Niloofar Rashidi Mahsa Sistani Sanaz Hadizadeh Razieh Razavi Ali Reza Farzinnejad Meysam Ahmadi Zeidabadi Somayeh Karami Mohajeri |
| author_sort | Mojgan Taebi |
| collection | DOAJ |
| description | The utilization of silver nanoparticles (AgNPs) in diverse fields, including medicine, is on the rise, leading to the development of a non-toxic and environmentally friendly synthesis method. This study presents a straightforward and stable one-step synthesis of AgNPs using an aqueous extract of Amygdalus lycioides as both a reducing and stabilizing agent. The experimental findings demonstrated that the presence of Amygdalus lycioides extract results in the formation of AgNPs with smaller size, uniformity, and well-dispersed nanostructures. The synthesis process is significantly influenced by certain reaction parameters such as the molar ratio of AgNO3, temperature, and extract volume. Characterization of the nanostructures was performed using XRD, UV-Vis, FT-IR, DLS, and SEM measurements. Furthermore, the AgNPs exhibited potent antibacterial effects, leading to cell death through increasing the membrane permeability and disrupting bacterial wall integrity. Additionally, this research explores the fungicidal characteristics of the colloidal solution of nanosized silver as a potential antifungal treatment against various plant pathogens. Based on the obtained results, AgNPs exhibit varying levels of antifungal activity against these plant pathogens. Molecular docking calculations revealed the binding energy between Ag metal and bacteria. These findings pave the way for effective and novel antimicrobial therapies as alternatives to traditional antifungal and antibacterial drugs, thereby addressing the challenges of microbial resistance and the difficulty of eradicating infections in the near future. |
| format | Article |
| id | doaj-art-634344fec4cc4a9eb0b7e8351030378f |
| institution | Kabale University |
| issn | 2538-4279 2423-818X |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Iranian Chemical Society |
| record_format | Article |
| series | Nanochemistry Research |
| spelling | doaj-art-634344fec4cc4a9eb0b7e8351030378f2025-01-12T10:25:08ZengIranian Chemical SocietyNanochemistry Research2538-42792423-818X2024-04-0192779010.22036/ncr.2023.418220.1330187338Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver NanoparticlesMojgan Taebi0Mahnaz Amiri1Niloofar Rashidi2Mahsa Sistani3Sanaz Hadizadeh4Razieh Razavi5Ali Reza Farzinnejad6Meysam Ahmadi Zeidabadi7Somayeh Karami Mohajeri8Department of Anesthesia,Faculty of Allied Medical Sciences,Kerman University of Medical Sciences,Kerman,IranNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, IranDepartment of Anesthesia, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences,Kerman, IranPathology and Stem Cell Research Center, Afzalipour Hospital, Kerman University of Medical Science, Kerman, IranDepartment of Medical Mycology & Parasitology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IranDepartment of chemistry, Faculty of Science, University of Jiroft, Jiroft, IranDepartment of Laboratory Hematology and Blood Banking, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, IranNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, IranDepartment of Toxicology and Pharmacology, School of PharmacyKerman University of Medical Sciences, Kerman, IranThe utilization of silver nanoparticles (AgNPs) in diverse fields, including medicine, is on the rise, leading to the development of a non-toxic and environmentally friendly synthesis method. This study presents a straightforward and stable one-step synthesis of AgNPs using an aqueous extract of Amygdalus lycioides as both a reducing and stabilizing agent. The experimental findings demonstrated that the presence of Amygdalus lycioides extract results in the formation of AgNPs with smaller size, uniformity, and well-dispersed nanostructures. The synthesis process is significantly influenced by certain reaction parameters such as the molar ratio of AgNO3, temperature, and extract volume. Characterization of the nanostructures was performed using XRD, UV-Vis, FT-IR, DLS, and SEM measurements. Furthermore, the AgNPs exhibited potent antibacterial effects, leading to cell death through increasing the membrane permeability and disrupting bacterial wall integrity. Additionally, this research explores the fungicidal characteristics of the colloidal solution of nanosized silver as a potential antifungal treatment against various plant pathogens. Based on the obtained results, AgNPs exhibit varying levels of antifungal activity against these plant pathogens. Molecular docking calculations revealed the binding energy between Ag metal and bacteria. These findings pave the way for effective and novel antimicrobial therapies as alternatives to traditional antifungal and antibacterial drugs, thereby addressing the challenges of microbial resistance and the difficulty of eradicating infections in the near future.http://www.nanochemres.org/article_187338_4a421ee450e7ef90c8797513a780f68d.pdfsilver nanoparticlegreen synthesisantifungal effectantibacterial activitycytotoxicityherbal extractmolecular docking |
| spellingShingle | Mojgan Taebi Mahnaz Amiri Niloofar Rashidi Mahsa Sistani Sanaz Hadizadeh Razieh Razavi Ali Reza Farzinnejad Meysam Ahmadi Zeidabadi Somayeh Karami Mohajeri Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles Nanochemistry Research silver nanoparticle green synthesis antifungal effect antibacterial activity cytotoxicity herbal extract molecular docking |
| title | Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles |
| title_full | Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles |
| title_fullStr | Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles |
| title_full_unstemmed | Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles |
| title_short | Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles |
| title_sort | antibacterial antifungal and cytotoxic properties as well as molecular docking evaluation of green synthesized silver nanoparticles |
| topic | silver nanoparticle green synthesis antifungal effect antibacterial activity cytotoxicity herbal extract molecular docking |
| url | http://www.nanochemres.org/article_187338_4a421ee450e7ef90c8797513a780f68d.pdf |
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