Burst-Free Sustained Release of Proteins from Thermal Gelling Polymer Solutions

<b>Objectives</b>: Thermo-gelling hydrophilic polymers like PLGA–PEG–PLGA are known as injectable sustained-release depots for biologics, but they face challenges due to the occurrence of severe burst release. This study aimed to develop a strategy to avoid the initial burst release by p...

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Bibliographic Details
Main Authors: Yuxing Zhang, Xixi Zou, Qiran Du, Xiaotao Dong, Uday Kumar Chinta, Ruyue Yu, Fei Wu, Tuo Jin
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
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Online Access:https://www.mdpi.com/1999-4923/17/3/376
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