Inhibitors of Tax1‐PDZ Interactions Block HTLV‐1 Viral Transmission by Changing EV Composition

Inhibitors of Tax1‐PDZ Interactions Block HTLV‐1 Viral Transmission by Changing EV Composition

ABSTRACT Extracellular vesicles (EVs) are known to facilitate infection by enveloped RNA viruses including the Human T‐cell leukemia virus type‐1 (HTLV‐1). HTLV‐1‐encoded proteins, like the transactivator and oncoprotein Tax‐1, are loaded into EVs but their precise impact on EV cargos is not yet kno...

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Main Authors: Jedidja Puttemans, Yasmine Brammerloo, Karim Blibek, Jeremy Blavier, Thandokuhle Ntombela, Inge Van Molle, Julie Joseph, Julien Olivet, Deeya Saha, Manon Degey, Malik Hamaidia, Pooja Jain, Piel Geraldine, Pascale Zimmermann, Dae‐Kyum Kim, Dominique Baiwir, Makon‐Sébastien Njock, Franck Dequiedt, Kourosh Salehi‐Ashtiani, Steven Ballet, Alexander N. Volkov, Jean‐Claude Twizere, Sibusiso B. Maseko
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of Extracellular Vesicles
Subjects:
interactome
miRNA
PDZ
syntenin‐1
Tax‐1
Online Access:https://doi.org/10.1002/jev2.70137
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https://doi.org/10.1002/jev2.70137

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