Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy.

Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy.

Exogenous CD1d-binding glycolipid (alpha-Galactosylceramide, alpha-GC) stimulates TCR signaling and activation of type-1 natural killer-like T (NKT) cells. Activated NKT cells play a central role in the regulation of adaptive and protective immune responses against pathogens and tumors. In the prese...

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Bibliographic Details
Main Authors: Sunil K Joshi, Gillian A Lang, Jason L Larabee, T Scott Devera, Lindsay M Aye, Hemangi B Shah, Jimmy D Ballard, Mark L Lang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000588&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000588&type=printable

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