Anti-inflammatory effect and a possible mechanism of action of ethowurtzine from the class of hexaazaizowurtzitane derivatives

Anti-inflammatory effect and a possible mechanism of action of ethowurtzine from the class of hexaazaizowurtzitane derivatives

Aim. To assess the anti-inflammatory and gastroprotective effects of ethowurtzine compared to the reference drug diclofenac in a rat model of chronic inflammation; to evaluate the influence of ethowurtzine on nitric oxide production as a possible mechanism of its anti-inflammatory effects.Materials...

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Main Authors: S. G. Krylova, E. A. Kiseleva, D. A. Kulagina, V. V. Eremina, E. Yu. Sherstoboev, A. A. Ligacheva, O. Yu. Rybalkina, E. P. Zueva, S. V. Sysolyatin, V. V. Zhdanov
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2025-07-01
Series:Бюллетень сибирской медицины
Subjects:
hexaazaisowurtzitane
ethowurtzine
inflammation
gastric toxicity
nitric oxide
Online Access:https://bulletin.ssmu.ru/jour/article/view/6053
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