RNA language models predict mutations that improve RNA function

RNA language models predict mutations that improve RNA function

Abstract Structured RNA lies at the heart of many central biological processes, from gene expression to catalysis. RNA structure prediction is not yet possible due to a lack of high-quality reference data associated with organismal phenotypes that could inform RNA function. We present GARNET (Gtdb A...

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Main Authors: Yekaterina Shulgina, Marena I. Trinidad, Conner J. Langeberg, Hunter Nisonoff, Seyone Chithrananda, Petr Skopintsev, Amos J. Nissley, Jaymin Patel, Ron S. Boger, Honglue Shi, Peter H. Yoon, Erin E. Doherty, Tara Pande, Aditya M. Iyer, Jennifer A. Doudna, Jamie H. D. Cate
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54812-y
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https://doi.org/10.1038/s41467-024-54812-y

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