Evaluation of hematologic parameters in children with Down syndrome
Objective: Congenital hematological disorders are frequently observed in Down syndrome (DS). In this study, we aimed to investigate peripheral blood-derived inflammation biomarkers such as neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and eosinophil/monocyte ratio in patients with Down syn...
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Selcuk University Press
2022-10-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2708351 |
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| author | Hasibe Artaç Hülya Özdemir |
| author_facet | Hasibe Artaç Hülya Özdemir |
| author_sort | Hasibe Artaç |
| collection | DOAJ |
| description | Objective: Congenital hematological disorders are frequently observed in Down syndrome (DS). In this study, we aimed to investigate peripheral blood-derived inflammation biomarkers such as neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and eosinophil/monocyte ratio in patients with Down syndrome.
Material and Methods: Ninety-eight patients with karyotypically ascertained DS and 103 healthy controls were included. All subjects were divided into three age groups: 0-2 years (34 patients, 34 controls), 2-6 years (32 patients, 33 controls), and >6 years (32 patients, 36 controls). Demographic, clinical, and laboratory data between June 2010 and December 2021 were written from the file records from the pediatric allergy and immunology department.
Results: Lymphocyte, eosinophil, and EMR were found to be significantly lower in children with DS compared to controls in group 2 (2-6 years) and group 3 (>6 years). PLR was found to be higher in children with DS in group 2 and group 3. There was no statistically significant difference between DS and controls in group 1 (6 years), there was a statistically significant difference between DS and controls in terms of lymphocyte, eosinophil, PLR, and EMR variables (P>0.05).
Conclusion: We found significant differences among lymphocyte, eosinophil, PLR, and EMR in patients with DS. As a result, these parameters should be evaluated carefully for clinical outcomes. |
| format | Article |
| id | doaj-art-621b71b27dce496c8f7f0c501d11cf56 |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-621b71b27dce496c8f7f0c501d11cf562025-01-02T23:43:04ZengSelcuk University PressGenel Tıp Dergisi2602-37412022-10-0132560560910.54005/geneltip.1189081154Evaluation of hematologic parameters in children with Down syndromeHasibe Artaç0Hülya Özdemir1SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİSelçuk Üniversitesi Tıp FakültesiObjective: Congenital hematological disorders are frequently observed in Down syndrome (DS). In this study, we aimed to investigate peripheral blood-derived inflammation biomarkers such as neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and eosinophil/monocyte ratio in patients with Down syndrome. Material and Methods: Ninety-eight patients with karyotypically ascertained DS and 103 healthy controls were included. All subjects were divided into three age groups: 0-2 years (34 patients, 34 controls), 2-6 years (32 patients, 33 controls), and >6 years (32 patients, 36 controls). Demographic, clinical, and laboratory data between June 2010 and December 2021 were written from the file records from the pediatric allergy and immunology department. Results: Lymphocyte, eosinophil, and EMR were found to be significantly lower in children with DS compared to controls in group 2 (2-6 years) and group 3 (>6 years). PLR was found to be higher in children with DS in group 2 and group 3. There was no statistically significant difference between DS and controls in group 1 (6 years), there was a statistically significant difference between DS and controls in terms of lymphocyte, eosinophil, PLR, and EMR variables (P>0.05). Conclusion: We found significant differences among lymphocyte, eosinophil, PLR, and EMR in patients with DS. As a result, these parameters should be evaluated carefully for clinical outcomes.https://dergipark.org.tr/tr/download/article-file/2708351down syndromeemrmlrnlrplrdown sendromuemrmlrnlrplr |
| spellingShingle | Hasibe Artaç Hülya Özdemir Evaluation of hematologic parameters in children with Down syndrome Genel Tıp Dergisi down syndrome emr mlr nlr plr down sendromu emr mlr nlr plr |
| title | Evaluation of hematologic parameters in children with Down syndrome |
| title_full | Evaluation of hematologic parameters in children with Down syndrome |
| title_fullStr | Evaluation of hematologic parameters in children with Down syndrome |
| title_full_unstemmed | Evaluation of hematologic parameters in children with Down syndrome |
| title_short | Evaluation of hematologic parameters in children with Down syndrome |
| title_sort | evaluation of hematologic parameters in children with down syndrome |
| topic | down syndrome emr mlr nlr plr down sendromu emr mlr nlr plr |
| url | https://dergipark.org.tr/tr/download/article-file/2708351 |
| work_keys_str_mv | AT hasibeartac evaluationofhematologicparametersinchildrenwithdownsyndrome AT hulyaozdemir evaluationofhematologicparametersinchildrenwithdownsyndrome |