Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells

Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells

Lipotoxicity refers to the harmful effects of excess fatty acids on metabolic health, and it can vary depending on the type of fatty acids involved. Saturated and unsaturated fatty acids exhibit distinct effects, though the precise mechanisms behind these differences remain unclear. Here, we investi...

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Bibliographic Details
Main Authors: Camilla Moliterni, Francesco Vari, Emily Schifano, Stefano Tacconi, Eleonora Stanca, Marzia Friuli, Serena Longo, Maria Conte, Stefano Salvioli, Davide Gnocchi, Antonio Mazzocca, Daniela Uccelletti, Daniele Vergara, Luciana Dini, Anna Maria Giudetti
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Lipid Research
Subjects:
diacylglycerol acyltransferase
endoplasmic reticulum stress
hepatic cells
lipid droplets
lipotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524001974
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