Bypassing the guardian: regulated cell death pathways in p53-mutant cancers

Abstract Approximately half of all cancers bear mutations in the tumor suppressor p53. Despite decades of research studying p53 function, treatment of p53-mutant cancers remains challenging owing to the effects of p53 mutations on many complex and interrelated signaling networks that promote tumor m...

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Bibliographic Details
Main Authors: Jonathan Y. Chung, Bruce A. Knutson
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cellular & Molecular Biology Letters
Subjects:
Online Access:https://doi.org/10.1186/s11658-025-00751-5
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