Bypassing the guardian: regulated cell death pathways in p53-mutant cancers
Abstract Approximately half of all cancers bear mutations in the tumor suppressor p53. Despite decades of research studying p53 function, treatment of p53-mutant cancers remains challenging owing to the effects of p53 mutations on many complex and interrelated signaling networks that promote tumor m...
Saved in:
| Main Authors: | Jonathan Y. Chung, Bruce A. Knutson |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
|
| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-025-00751-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
VDAC2 Mediates the Apoptosis of Cashmere Goat Hair Follicle Stem Cells Through the P53 Signaling Pathway
by: Long Zhu, et al.
Published: (2025-06-01) -
DNA Damage-Induced Ferroptosis: A Boolean Model Regulating p53 and Non-Coding RNAs in Drug Resistance
by: Shantanu Gupta, et al.
Published: (2025-01-01) -
A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death
by: Sophia Ceder, et al.
Published: (2020-12-01) -
Programmed Cell Death in Heart Failure: Mechanisms, Impacts, and Therapeutic Prospects
by: Dongda Wu, et al.
Published: (2025-07-01) -
p53 in colorectal cancer: from a master player to a privileged therapy target
by: Sicheng Yan, et al.
Published: (2025-06-01)