Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1

Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1

Summary: Sterols target sterol-sensing domain (SSD) proteins to lower cholesterol and circulating and hepatic triglyceride levels, but the mechanism remains unclear. In this study, we identify acyl-coenzyme A (CoA) synthetase long-chain family member 1 (ACSL1) as a direct target of ergosterol (ES)....

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Main Authors: Zu-Guo Zheng, Yi-Ping Zhang, Xiao-Yu Zhang, Meng-Yao Qin, Yin-Yue Xu, He Wu, Run-Qing Liu, Qiu-Yi Wu, Ming-Su Wang, Chong Zhang, Yue-Qin Zheng, Jian-Ye Dai, Ping Li, Hua Yang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724015547
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