Promoter Methylation Precedes Chromosomal Alterations in Colorectal Cancer Development

Promoter Methylation Precedes Chromosomal Alterations in Colorectal Cancer Development

Background: Colorectal cancers are characterized by genetic and epigenetic alterations. This study aimed to explore the timing of promoter methylation and relationship with mutations and chromosomal alterations in colorectal carcinogenesis. Methods: In a series of 47 nonprogressed adenomas, 41 progr...

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Main Authors: Sarah Derks, Cindy Postma, Peter T. M. Moerkerk, Sandra M. van den Bosch, Beatriz Carvalho, Mario A. J. A. Hermsen, Walter Giaretti, James G. Herman, Matty P. Weijenberg, Adriaan P. de Bruïne, Gerrit A. Meijer, Manon van Engeland
Format: Article
Language:English
Published: Wiley 2006-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.1155/2006/846251
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http://dx.doi.org/10.1155/2006/846251

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