Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA?
Background: Glucocorticoids increase fear extinction in preclinical and human studies. Endogenous cortisol might influence who will benefit from exposure therapy in anxiety-spectrum disorders. Methods: To investigate the impact of cortisol levels on within-session habituation of distress – a measure...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_566_24 |
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| author | Michael Kellner Alexander Yassouridis Christoph Muhtz Klaus Wiedemann |
| author_facet | Michael Kellner Alexander Yassouridis Christoph Muhtz Klaus Wiedemann |
| author_sort | Michael Kellner |
| collection | DOAJ |
| description | Background:
Glucocorticoids increase fear extinction in preclinical and human studies. Endogenous cortisol might influence who will benefit from exposure therapy in anxiety-spectrum disorders.
Methods:
To investigate the impact of cortisol levels on within-session habituation of distress – a measure of success of exposure therapy – in obsessive-compulsive disorder (OCD) fifty-one OCD patients were studied during their stressful first cognitive-behavioral exposure therapy session with response prevention. Subjective units of distress, salivary cortisol, and salivary dehydroepiandrosterone (DHEA) were measured repeatedly before and during this afternoon session.
Results:
No significant association of within-session habituation of distress and cortisol level during exposure was found. Calculating with the cortisol/DHEA ratio, similar results emerged.
Conclusion:
Studies using endogenous diurnal fluctuation of cortisol and studies with administration of exogenous cortisol are needed to test whether glucocorticoids can augment exposure session outcome. |
| format | Article |
| id | doaj-art-617b78eb3d054900a80d33a0f69f4ff3 |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-617b78eb3d054900a80d33a0f69f4ff32025-01-07T06:32:29ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942024-12-0166121150115310.4103/indianjpsychiatry.indianjpsychiatry_566_24Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA?Michael KellnerAlexander YassouridisChristoph MuhtzKlaus WiedemannBackground: Glucocorticoids increase fear extinction in preclinical and human studies. Endogenous cortisol might influence who will benefit from exposure therapy in anxiety-spectrum disorders. Methods: To investigate the impact of cortisol levels on within-session habituation of distress – a measure of success of exposure therapy – in obsessive-compulsive disorder (OCD) fifty-one OCD patients were studied during their stressful first cognitive-behavioral exposure therapy session with response prevention. Subjective units of distress, salivary cortisol, and salivary dehydroepiandrosterone (DHEA) were measured repeatedly before and during this afternoon session. Results: No significant association of within-session habituation of distress and cortisol level during exposure was found. Calculating with the cortisol/DHEA ratio, similar results emerged. Conclusion: Studies using endogenous diurnal fluctuation of cortisol and studies with administration of exogenous cortisol are needed to test whether glucocorticoids can augment exposure session outcome.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_566_24cortisoldheaexposurehabituationocd |
| spellingShingle | Michael Kellner Alexander Yassouridis Christoph Muhtz Klaus Wiedemann Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA? Indian Journal of Psychiatry cortisol dhea exposure habituation ocd |
| title | Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA? |
| title_full | Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA? |
| title_fullStr | Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA? |
| title_full_unstemmed | Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA? |
| title_short | Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA? |
| title_sort | within session habituation and salivary cortisol during exposure treatment in obsessive compulsive disorder a link and an influence of dhea |
| topic | cortisol dhea exposure habituation ocd |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_566_24 |
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