Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases
Abstract Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. Wearable sensors, like inertial measurement units (IMUs), offer a way to monitor dail...
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| Format: | Article |
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Nature Portfolio
2025-01-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-024-01386-0 |
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| author | Robbin Romijnders Arash Atrsaei Rana Zia Ur Rehman Lea Strehlow Jèrôme Massoud Chloe Hinchliffe Victoria Macrae Kirsten Emmert Ralf Reilmann C. Janneke van der Woude Geert Van Gassen Frédéric Baribaud Teemu Ahmaniemi Meenakshi Chatterjee Bruno Kusznir Vitturi Clémence Pinaud Jérôme Kalifa Stefan Avey Wan-Fai Ng Clint Hansen Nikolay V. Manyakov Walter Maetzler |
| author_facet | Robbin Romijnders Arash Atrsaei Rana Zia Ur Rehman Lea Strehlow Jèrôme Massoud Chloe Hinchliffe Victoria Macrae Kirsten Emmert Ralf Reilmann C. Janneke van der Woude Geert Van Gassen Frédéric Baribaud Teemu Ahmaniemi Meenakshi Chatterjee Bruno Kusznir Vitturi Clémence Pinaud Jérôme Kalifa Stefan Avey Wan-Fai Ng Clint Hansen Nikolay V. Manyakov Walter Maetzler |
| author_sort | Robbin Romijnders |
| collection | DOAJ |
| description | Abstract Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. Wearable sensors, like inertial measurement units (IMUs), offer a way to monitor daily activities and evaluate functional capacity. This study investigates the relationship between sit-to-stand and stand-to-sit transitions and self-reported physical and mental fatigue in participants with Parkinson’s, Huntington’s, rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren’s syndrome and inflammatory bowel disease. Over 4 weeks, participants wore an IMU and reported fatigue levels four times daily. Using mixed-effects models, associations were identified between fatigue and specific kinematic features, such as 5th and 95th percentiles of sit-to-stand performance, suggesting that fatigue alters the control and effort of movement. These kinematic features show promise as indicators for fatigue in these patient populations. |
| format | Article |
| id | doaj-art-6178d8b34eb74839a8becd0ea40c8af3 |
| institution | Kabale University |
| issn | 2398-6352 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Digital Medicine |
| spelling | doaj-art-6178d8b34eb74839a8becd0ea40c8af32025-01-12T12:40:54ZengNature Portfolionpj Digital Medicine2398-63522025-01-01811910.1038/s41746-024-01386-0Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseasesRobbin Romijnders0Arash Atrsaei1Rana Zia Ur Rehman2Lea Strehlow3Jèrôme Massoud4Chloe Hinchliffe5Victoria Macrae6Kirsten Emmert7Ralf Reilmann8C. Janneke van der Woude9Geert Van Gassen10Frédéric Baribaud11Teemu Ahmaniemi12Meenakshi Chatterjee13Bruno Kusznir Vitturi14Clémence Pinaud15Jérôme Kalifa16Stefan Avey17Wan-Fai Ng18Clint Hansen19Nikolay V. Manyakov20Walter Maetzler21Department of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel UniversityMindmaze SA, Digital Motion Analytics TeamJanssen, Johnson & JohnsonDepartment of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel UniversityDepartment of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel UniversityTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle UniversityTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle UniversityDepartment of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel UniversityGeorge-Huntington-InstituteErasmus MCMedical Affairs, Takeda Belgium NVTranslational Development, Bristol Meyers SquibbVTT Technical Research Centre of Finland LtdJanssen Research & DevelopmentDepartment of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel UniversityLet It CareLet It CareJanssen Research & DevelopmentTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle UniversityDepartment of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel UniversityJanssen Research & DevelopmentDepartment of Neurology, University Hospital Schleswig-Holstein Campus Kiel, Kiel UniversityAbstract Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. Wearable sensors, like inertial measurement units (IMUs), offer a way to monitor daily activities and evaluate functional capacity. This study investigates the relationship between sit-to-stand and stand-to-sit transitions and self-reported physical and mental fatigue in participants with Parkinson’s, Huntington’s, rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren’s syndrome and inflammatory bowel disease. Over 4 weeks, participants wore an IMU and reported fatigue levels four times daily. Using mixed-effects models, associations were identified between fatigue and specific kinematic features, such as 5th and 95th percentiles of sit-to-stand performance, suggesting that fatigue alters the control and effort of movement. These kinematic features show promise as indicators for fatigue in these patient populations.https://doi.org/10.1038/s41746-024-01386-0 |
| spellingShingle | Robbin Romijnders Arash Atrsaei Rana Zia Ur Rehman Lea Strehlow Jèrôme Massoud Chloe Hinchliffe Victoria Macrae Kirsten Emmert Ralf Reilmann C. Janneke van der Woude Geert Van Gassen Frédéric Baribaud Teemu Ahmaniemi Meenakshi Chatterjee Bruno Kusznir Vitturi Clémence Pinaud Jérôme Kalifa Stefan Avey Wan-Fai Ng Clint Hansen Nikolay V. Manyakov Walter Maetzler Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases npj Digital Medicine |
| title | Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases |
| title_full | Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases |
| title_fullStr | Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases |
| title_full_unstemmed | Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases |
| title_short | Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases |
| title_sort | association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases |
| url | https://doi.org/10.1038/s41746-024-01386-0 |
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