Phosphodiesterase 9 Inhibition Combined With Valsartan and With Sacubitril/Valsartan in Experimental Ovine Heart Failure

Phosphodiesterase 9 Inhibition Combined With Valsartan and With Sacubitril/Valsartan in Experimental Ovine Heart Failure

Background LCZ696 (sacubitril/valsartan) antagonizes the renin–angiotensin system while simultaneously augmenting the natriuretic peptides (NPs). Inhibition of phosphodiesterase 9 inhibition (PDE9i), which hydrolyses NP‐generated cGMP may be a more specific means of enhancing NP bioactivity. The obj...

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Bibliographic Details
Main Authors: Nicola J. A. Scott, Christopher J. Charles, Timothy C. R. Prickett, Christopher M. Frampton, A. Mark Richards, Miriam T. Rademaker
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cyclic guanosine monophosphate
heart failure
natriuretic peptides
neprilysin
phosphodiesterase 9
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.036689
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https://www.ahajournals.org/doi/10.1161/JAHA.124.036689

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