Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with α-Synucleinopathy

Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with α-Synucleinopathy

This study investigated the therapeutic potential of the nuclear retinoid X receptor (RXR) in mitigating the progression of alpha-synucleinopathies (αSNPs), particularly in Parkinson’s disease (PD). PD-like pathology in mice was successfully induced through the co-delivery of AAV expressing human α-...

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Bibliographic Details
Main Authors: Assylbek Zhylkibayev, Christopher R. Starr, M. Iqbal Hossain, Sandeep Kumar, Shaida A. Andrabi, Maria B. Grant, Venkatram R. Atigadda, Marina S. Gorbatyuk, Oleg S. Gorbatyuk
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
α-synucleinopathy
Parkinson’s disease
retinoid X receptor
α-synuclein
Lewy body
dopamine
Online Access:https://www.mdpi.com/2073-4409/14/10/685
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