Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection
Abstract Exosomes, secreted by various types of cells, play a crucial role in cell‐to‐cell communication by transporting essential molecular cargos that largely mirror the pathophysiological attributes of their parent cells. Increasing evidence has shown that exosomes emerge as the reliable early bi...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-01-01
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| Series: | Advanced Sensor Research |
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| Online Access: | https://doi.org/10.1002/adsr.202400002 |
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| author | Jingyu Sun Wei Hu Nuo Xu Jonathan Makris Felicia Spadavecchia Hongjun Wang |
| author_facet | Jingyu Sun Wei Hu Nuo Xu Jonathan Makris Felicia Spadavecchia Hongjun Wang |
| author_sort | Jingyu Sun |
| collection | DOAJ |
| description | Abstract Exosomes, secreted by various types of cells, play a crucial role in cell‐to‐cell communication by transporting essential molecular cargos that largely mirror the pathophysiological attributes of their parent cells. Increasing evidence has shown that exosomes emerge as the reliable early biomarkers for different diseases. Clearly, exosomal detection with a high sensitivity and specificity becomes highly essential to advance the understanding of disease progression and to develop early diagnostic modalities. Among different types of biosensors, aptasensors have received significant attention as the diagnostic tools considering their programmability and targeting ability. Noble metal nanomaterials possess distinctive physicochemical properties, allowing for ready functionalization with aptamers via both physical adsorption and chemical immobilization. By utilizing the aptamers as the recognition elements, noble metal nanoparticle‐based aptasensors offer a promising platform for rapid, cost‐effective, and sensitive in situ detection of exosomes. In this review, the progress will summarized in exosomes as a biomarker for diseases and the recent advances in the use of noble metal nanoparticle/aptamer‐based sensors for analysis of exosomes and other extracellular vesicles. |
| format | Article |
| id | doaj-art-6023764eb0324dc3809f728e95441a61 |
| institution | Kabale University |
| issn | 2751-1219 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Sensor Research |
| spelling | doaj-art-6023764eb0324dc3809f728e95441a612025-01-09T21:16:46ZengWiley-VCHAdvanced Sensor Research2751-12192025-01-0141n/an/a10.1002/adsr.202400002Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal DetectionJingyu Sun0Wei Hu1Nuo Xu2Jonathan Makris3Felicia Spadavecchia4Hongjun Wang5Department of Biomedical Engineering Stevens Institute of Technology Hoboken NJ 07030 USADepartment of Chemistry and Chemical Biology Stevens Institute of Technology Hoboken NJ 07030 USADepartment of Biomedical Engineering Stevens Institute of Technology Hoboken NJ 07030 USADepartment of Biomedical Engineering Stevens Institute of Technology Hoboken NJ 07030 USADepartment of Chemistry and Chemical Biology Stevens Institute of Technology Hoboken NJ 07030 USADepartment of Biomedical Engineering Stevens Institute of Technology Hoboken NJ 07030 USAAbstract Exosomes, secreted by various types of cells, play a crucial role in cell‐to‐cell communication by transporting essential molecular cargos that largely mirror the pathophysiological attributes of their parent cells. Increasing evidence has shown that exosomes emerge as the reliable early biomarkers for different diseases. Clearly, exosomal detection with a high sensitivity and specificity becomes highly essential to advance the understanding of disease progression and to develop early diagnostic modalities. Among different types of biosensors, aptasensors have received significant attention as the diagnostic tools considering their programmability and targeting ability. Noble metal nanomaterials possess distinctive physicochemical properties, allowing for ready functionalization with aptamers via both physical adsorption and chemical immobilization. By utilizing the aptamers as the recognition elements, noble metal nanoparticle‐based aptasensors offer a promising platform for rapid, cost‐effective, and sensitive in situ detection of exosomes. In this review, the progress will summarized in exosomes as a biomarker for diseases and the recent advances in the use of noble metal nanoparticle/aptamer‐based sensors for analysis of exosomes and other extracellular vesicles.https://doi.org/10.1002/adsr.202400002aptameraptasensorexosomal detectionexosomenanosensornoble metal nanoparticle |
| spellingShingle | Jingyu Sun Wei Hu Nuo Xu Jonathan Makris Felicia Spadavecchia Hongjun Wang Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection Advanced Sensor Research aptamer aptasensor exosomal detection exosome nanosensor noble metal nanoparticle |
| title | Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection |
| title_full | Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection |
| title_fullStr | Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection |
| title_full_unstemmed | Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection |
| title_short | Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection |
| title_sort | noble metal nanoparticle based aptasensors a powerful tool for exosomal detection |
| topic | aptamer aptasensor exosomal detection exosome nanosensor noble metal nanoparticle |
| url | https://doi.org/10.1002/adsr.202400002 |
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