4′-Demethylpodophyllotoxin functions as a mechanism-driven therapy by targeting the PI3K-AKT pathway in Colorectal cancer

4′-Demethylpodophyllotoxin functions as a mechanism-driven therapy by targeting the PI3K-AKT pathway in Colorectal cancer

The treatment of colorectal cancer (CRC) poses significant challenges in terms of drug resistance and poor prognosis, necessitating the exploration of effective therapeutic strategies. In this study, high-throughput drug screening was utilized to identify Chinese herbal medicines with notable therap...

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Main Authors: Jun Liu, Dandong Luo, Xiaochuan Chen, Jiaqi Liu, Junxiong Chen, Mengchen Shi, Haiyan Dong, Yucheng Xu, Xinyou Wang, Zhaoliang Yu, Huanliang Liu, Yanchun Feng
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Translational Oncology
Subjects:
4′-Demethylpodophyllotoxin
PI3K-AKT pathway
Chemoresistance
Colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324003255
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