Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation

Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation

Abstract Personalized protein corona significantly influences the biodistribution and therapeutic efficacy of nanomedicines, generating unique profiles that can impact treatment outcomes. Here, we demonstrate that pegylated liposomal doxorubicin (PLD) exhibits increased tumor accumulation and enhanc...

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Bibliographic Details
Main Authors: Shiyi Xu, Nana Bie, Xinzhuang Su, Xiaojuan Zhang, Shiyu Li, Haojie Liu, Tuying Yong, Qing Chen, Xiangliang Yang, Lu Gan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Nanobiotechnology
Subjects:
Protein corona
Pegylated liposomal doxorubicin
Tumor-targeted delivery
Obesity
Complement component 1q
Online Access:https://doi.org/10.1186/s12951-025-03635-0
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